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GreenDust@lemmings.world to Lemmy Shitpost@lemmy.world · 5 days ago

Grapefruit Redbull

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Grapefruit Redbull

lemmings.world

GreenDust@lemmings.world to Lemmy Shitpost@lemmy.world · 5 days ago
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  • SingularEye@lemmy.blahaj.zone
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    3 days ago

    I don’t get it

    • GeneralVincent@lemmy.world
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      2 days ago

      No grapefruit while taking ssri medication

      edit: sorry, this is a bit misleading and an oversimplification

      https://en.wikipedia.org/wiki/Grapefruit–drug_interactions

      • sem@piefed.blahaj.zone
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        2 days ago

        Wait…

        I don’t think that’s true. If it were, they’d put it in the instructions that come with the SSRI medicines.

        And it is not on the list of drugs on this web page. https://www.fda.gov/consumers/consumer-updates/grapefruit-juice-and-some-drugs-dont-mix

        • GeneralVincent@lemmy.world
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          2 days ago

          Yup, I made a bad generalization. My bad, and to be clear I’m not a doctor or anything.

          Some SSRIs may have an interaction with grapefruit. But grapefruit interacts with different medications differently, and it’s not based on the class of medication, it’s med specific.

          e.g. Sertraline (Zoloft) is an SSRI and is listed as having an interaction with grapefruit

          https://en.wikipedia.org/wiki/Grapefruit–drug_interactions

          Eta: thanks for calling that out, I’ve learned some interesting things, for example;

          Ketamine: After drinking 200 mL of grapefruit juice daily for five days, the overall absorption of orally ingested ketamine was increased three-fold compared to the control group in a clinical trial. The peak blood ketamine concentration was increased over two-fold.

          • sem@piefed.blahaj.zone
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            2 days ago

            That is so weird. Here is the study: https://pubmed.ncbi.nlm.nih.gov/10890261/

            It was only n=5 but my layperson understanding is that the results were significant.

            Either I’ve never noticed a grapefruit warning (and at one time I read the documentation fully) or Sertraline doesn’t come with one…

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